Buruli Ulcer - Infection that Consumes Skins

Buruli Ulcer is a disease caused by infection by the Mycobacterium ulcerans. It is one of the most neglected disease in the world, specifically in the developing countries. Mycobacterium (other bacteria of the same family) is also the bacteria that causes tuberculosis and leprosis; however, Buruli ulcer has received the least attention.

Infection of this disease occurs mainly in tropical areas such as Australia, West Africa, Southeast Asia and New Guinea. Among which, this disease has the largest impact in developing countries, mainly due to the lack of knowledge in the disease.

It has been reported that the mycobacteria strives within aquatic environments (such as small aquatic animals, biofilms). Transmission mode to humans is still under investigation. Thus, Buruli ulcers usually occurs near water sources, infecting children under 15 years mainly. There is no evidence that this disease can be transmitted from person to person.

A young boy with Buruli ulcers
Picture Source: click here

Symptoms in General

Buruli ulcer begins with a painless mobile swelling in the skin (any part of the body). The more severe infection can be painful. Buruli ulcer is a long term, necrotizing disease that slowly destroys the skin and soft tissue by the toxin secreted by the mycobacteria.Without treatment, massive ulcerations take place and if the bone is affected, gross deformities will be the consequence.  If the ulcers develop on the limbs, the movement of the patients will be greatly restricted; even after the lesions have healed, the massive scarring will affect the mobility of the patients. In more severe cases, lifetime disabilities are norm in the patients. Can you imagine the pain the patients are enduring?

Treatment And Prevention

The most efficient treatment of Buruli ulcer is the surgical removal of the ulcers. For disease in more advanced stage, prolonged treatment with skin grafting will be necessary. However, surgical practice is scarcely available in developing countries. A combination of antibiotics can be used to reduce the requirement for surgery.

Bacille Calmette–Guérin (BCG) vaccination has been observed to provide short-term protection against the disease. Although only limited protection is available, it will still be useful by ensuring a complete coverage of this vaccine in the heavily affected regions. Once again, people in developing countries have very minor chances to receive such vaccination due to extreme poverty as well as lack of knowledge in diseases.

The Leatfcutter Cultivation of Fungus

Brief description:

The Leafcutter ants build their fortress underground. They collect a kind of leaves (non-edible) in order to cultivate a species of fungus in their nest. The fungus has the ability to break down the toxins in the leaves, and in turn the fungus will swell with proteins and sugar. This swollen fungus which are rich in proteins and sugar is the food source of the leafcutter ants.

The ants and the fungus depend on each other for a living. Leafcutter ants see the fungus as a source of food. On the other hand, the fungus depend on the ants to bring in food for them (in this case, the leaves). The fungus also seek protection from the ants against a type of mould that will grow on the fungus and wipe them out.

Interestingly, the ants's body have bacteria to produce an antibiotics against the mould. The antibiotics supresses the growth of mould on their food source in the nest!